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dr. S.G. (Sjoerd) Elias

dr. S.G. (Sjoerd) Elias

Associate Professor
dr. S.G. (Sjoerd) Elias
  • Julius Center, dept. Epidemiology & Health Economics

Research Programs

Cancer

Biography

Biography

I obtained my MSc in Clinical Epidemiology at the Netherlands Institute for Health Sciences (2002), and my PhD at Utrecht University (2003). Following graduation from Medical School in 2005 I worked as a resident in radiology (Gelre Ziekenhuizen Apeldoorn, the Netherlands, 2006-2007). A personal Dutch Cancer Society Research Fellowship (2009-2013) enabled me to work as a visiting scientist at the Molecular Imaging Program at Stanford (professor SS Gambhir), the Department of Radiology and Biomedical Imaging at the University of California San Francisco (professor NM Hylton), and the Department of Molecular Pathology at the Netherlands Cancer Institute (professor LJ van't Veer). Since 2008, I work as a Clinical Epidemiologist in the research programs Cancer and Methodology at the Julius Center for Health Sciences and Primary Care, since 2018 as Associate Professor. Furthermore, I have more than ten years of experience in teaching and coordinating courses in clinical epidemiology, both nationally as well as internationally. Since 2020 I am coordinator of the PhD program Clinical and Translational Oncology, and since 2021 I am coordinator of the Research Program Cancer and management team member of the Epidemiology department of the Julius Center, as well as board member of the UMC Utrecht Strategic Program Cancer.

Interests and Focus

My main research focus is on the clinical evaluation and translation of biomarkers, particularly for cancer classification (i.e. diagnostic, prognostic, and predictive markers). These markers include emerging imaging technologies such as molecular imaging, omics-based tests, and organoids. I have both experience in preclinical research as well as applied clinical science, and have expertise and experience in the design and analysis of studies spanning all (translation) phases of biomarker development, as well as treatment studies (from phase I through phase III).

Side Activities

- Board member of the UMC Utrecht Strategic Program Cancer.

- Coordinator of the Research Program Cancer of the Julius Center.

- Coordinator of the PhD program Clinical and Translational Oncology.

- Coordinator of the SUMMA course "Wetenschappelijke Vorming - Onderzoeksmethodologie" ("applied clinical research").

- Coordinator of the MSc Epidemiology course "Advanced Topics in Causal Research: Confounding and Effect-Modification".

- Member of the Internal Review Committee Exploration of the Dutch Cancer Society.

- Member of the Dutch Association for Epidemiology (Vereniging voor Epidemiologie), Registration as Senior Epidemiologist (B) (SMBWO, 2006).

Fellowship and Awards

2022: Voted best lecturer of the year by the Selective Utrecht Medical Master program students, Utrecht University

2016-2017: Jury member of the Talma Eykman award, UMC Utrecht.

2016-2017: Jury member of the Frits de Waard Penning, UMC Utrecht.

2014: Epidemiology teacher of the year, Epidemiology department, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht.

2014: Voted best lecturer of the year by the Selective Utrecht Medical Master program students, Utrecht University.

2013-2016: Methodologist of the Medical Ethical Review Board of the UMC Utrecht.

2013: UMC Utrecht Research Talent Program.

2012: Invitee, 2nd Inspire2Live annual conference at the Royal Netherlands Academy of Arts and Sciences (meeting of talented young international cancer scientists).

2011: René Vogels Foundation travel grant.

2009: Dutch Cancer Society Research Fellowship (four year personal grant).

Research Output (202)

Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR):protocol of a phase I dose-escalation trial

Verweij Maaike E, Tanaka Max D, Kensen Chavelli M, van der Heide Uulke A, Marijnen Corrie A M, Janssen Tomas, Vijlbrief Tineke, van Grevenstein Wilhelmina M U, Moons Leon M G, Koopman Miriam, Lacle Miangela M, Braat Manon N G J A, Chalabi Myriam, Maas Monique, Huibregtse Inge L, Snaebjornsson Petur, Grotenhuis Brechtje A, Fijneman Remond, Consten Esther, Pronk Apollo, Smits Anke B, Heikens Joost T, Eijkelenkamp Hidde, Elias Sjoerd G, Verkooijen Helena M, Schoenmakers Maartje M C, Meijer Gert J, Intven Martijn, Peters Femke P 15 Jun 2023, In: BMJ Open. 13 , p. 1-10

Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

Millen Rosemary, De Kort Willem W.B., Koomen Mandy, van Son Gijs J.F., Gobits Roán, Penning de Vries Bas, Begthel Harry, Zandvliet Maurice, Doornaert Patricia, Raaijmakers Cornelis P.J., Geurts Maarten H., Elias Sjoerd G., van Es Robert J.J., de Bree Remco, Devriese Lot A., Willems Stefan M., Kranenburg Onno, Driehuis Else, Clevers Hans 12 May 2023, In: Med. 4 , p. 290-310.e12

Long-term Survival in Breast Cancer Patients Is Associated with Contralateral Parenchymal Enhancement at MRI:Outcomes of the SELECT Study

Ragusi Max A.A., van der Velden Bas H.M., Meeuwis Carla, Tetteroo Eric, Coerkamp Emile G., van Nijnatten Thiemo J.A., Jansen Frits H., Wolters-Van Der Ben Elian J.M., Jongen Lisa, van Raamt Fleur, Dorrius Monique D., Verloop Janneke, Viergever Max A., Pijnappel Ruud M., Elias Sjoerd G., Gilhuijs Kenneth G.A. May 2023, In: Radiology. 307 , p. 1-8

Fibroblast Activation Protein Inhibitor-PET Imaging in Colorectal Cancer

Strating Esther, van de Loo Anne, Elias Sjoerd, Lam Marnix, Kranenburg Onno 6 Apr 2023, In: PET Clinics. 18 , p. 325-335 11 p.

Predicting early extrahepatic recurrence after local treatment of colorectal liver metastases

Wensink G. E., Bolhuis Karen, Elferink Marloes A.G., Fijneman Remond J.A., Kranenburg Onno, Borel Rinkes Inne H.M., Koopman Miriam, Swijnenburg Rutger Jan, Vink Geraldine R., Hagendoorn Jeroen, Punt Cornelis J.A., Roodhart Jeanine M.L., Elias Sjoerd G. 1 Mar 2023, In: British Journal of Surgery. 110 , p. 362-371 10 p.

CT radiomics compared to a clinical model for predicting checkpoint inhibitor treatment outcomes in patients with advanced melanoma

Ter Maat Laurens S, van Duin Isabella A J, Elias Sjoerd G, Leiner Tim, Verhoeff Joost J C, Arntz Eran R A N, Troenokarso Max F, Blokx Willeke A M, Isgum Ivana, de Wit Geraldine A, van den Berkmortel Franchette W P J, Boers-Sonderen Marye J, Boomsma Martijn F, van den Eertwegh Fons J M, de Groot Jan Willem B, Piersma Djura, Vreugdenhil Art, Westgeest Hans M, Kapiteijn Ellen, van Diest Paul J, Pluim Josien P W, de Jong Pim A, Suijkerbuijk Karijn P M, Veta Mitko 24 Feb 2023, In: European Journal of Cancer. 185 , p. 167-177 11 p.

Development and validation of risk calculators for people with "thin" melanomas on their skin to predict the likelihood that their cancer will return:a plain language summary of publication

Sharouni Mary-Ann El, Lo Serigne N, Varey Alexander Hr, Elias Sjoerd G, Witkamp Arjen J, Sigurdsson Vigfús, Suijkerbuijk Karijn Pm, van Diest Paul J, van Gils Carla H, Blokx Willeke Am, Scolyer Richard A, Thompson John F Jan 2023, In: Future Oncology. 19 , p. 97-102 6 p.

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

Strating Esther, Verhagen Mathijs P, Wensink Emerens, Dünnebach Ester, Wijler Liza, Aranguren Itziar, De la Cruz Alberto Sanchez, Peters Niek A, Hageman Joris H, van der Net Mirjam M C, van Schelven Susanne, Laoukili Jamila, Fodde Riccardo, Roodhart Jeanine, Nierkens Stefan, Snippert Hugo, Gloerich Martijn, Rinkes Inne Borel, Elias Sjoerd G, Kranenburg Onno 2023, In: Frontiers in Immunology. 14

Time interval from primary melanoma to first distant recurrence in relation to patient outcomes in advanced melanoma

van Duin Isabella A.J., Elias Sjoerd G., van den Eertwegh Alfonsus J.M., de Groot Jan Willem B., Blokx Willeke A.M., van Diest Paul J., Leiner Tim, Verhoeff Joost J.C., Verheijden Rik J., van Not Olivier J., Aarts Maureen J.B., van den Berkmortel Franchette W.P.J., Blank Christian U., Haanen John B.A.G., Hospers Geke A.P., Kamphuis Anna M., Piersma Djura, van Rijn Rozemarijn S., van der Veldt Astrid A.M., Vreugdenhil Gerard, Wouters Michel W.J.M., Stevense-den Boer Marion A.M., Boers-Sonderen Marye J., Kapiteijn Ellen, Suijkerbuijk Karijn P.M. 2023, In: International Journal of Cancer. 152 , p. 2493-2502 10 p.

Risk Modeling for Individualization of the FLAME Focal Boost Approach in External Beam Radiation Therapy for Patients With Localized Prostate Cancer

Menne Guricová Karolína, Groen Veerle, Pos Floris, Monninkhof Evelyn, Elias Sjoerd G., Haustermans Karin, Smeenk Robert J., van der Voort van Zyp Jochem, Draulans Cédric, Isebaert Sofie, van Houdt Petra J., Kerkmeijer Linda G.W., van der Heide Uulke A. 2023, In: International Journal of Radiation Oncology Biology Physics. 118 , p. 66-73 8 p.

All research output

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