prof. dr. R. (Richard) van Hillegersberg

prof. dr. R. (Richard) van Hillegersberg

Full Professor
prof. dr. R. (Richard) van Hillegersberg
  • Department of Surgical Oncology

Research Programs




Richard van Hillegersberg attended medical school in Rotterdam, the Netherlands. In 1993 he received his PhD with honor at the Department of Surgery, Erasmus MC in Rotterdam. From 1994-2000, he was trained in General Surgery in Rotterdam. From 2001-2002 he was fellow of Surgical Oncology in the Academic Medical Center and Antoni van Leeuwenhoek Netherlands Cancer Center Amsterdam. Since 2003 he is appointed as staff surgeon at the University Medical Center Utrecht. From 2009 he is a full professor of gastrointestinal oncology. Research is focused on Upper GI minimally invasive and robotic surgery, surgical imaging and genetic profiling. He has authored over 15 chapters in textbooks concerning robotic forgut surgery and over 500 articles in international peer-reviewed journals. From 2018 he is chairman of the Educational committee of the European Society for Diseases for the Esophagus (ESDE) and member of the education committee of ISDE, he is associate editor of Diseases of the Esophagus and Digestive Surgery, founder and chairman of the Upper GI International Robotic Association (UGIRA).

Side Activities

Member board and educational committee Europen Society Diseases of the Esophagus (ESDE)

Member Council European Digestive Surgery

Member Scientific Committee United European Gastroenterology (UEG)

Member Committee Dutch Guidelines oesophageal cancer

Member board Dutch UpperGI Cancer Audit (DUCA)

Associate editor Digestive Surgery

Associate editor Diseases of the Esophagus

Proctor Upper GI robotic Surgery Intuitive Surgical (paid)

Fellowship and Awards

2014-present. Principle investigator. Cost effectiveness of laparoscopic gastrectomy  as an alternative to open gastrectomy for gastric cancer (LOGICA trial). NCT02248519. ZonMw (837002502) Eu 400.000

2014-present. Principle investigator. Esophagectomy for Patients With Esophageal Cancer and Cervical Lymph Node Metastases (NODE trial). NCT02426879

2017-present. Intuitive Clinical Research Grant for the project “The International Registry for Robot-assisteted Minimally Invasive Esophagectomy” (RAMIE). Unrestricted Grant $ 50.000

2017-present. International Database collaboration Robotic esophagectomy, Intuitive Surgical, Unrestricted Grant. Eu 50.000

 2017-present. Coordinating Investigator of International Centers. Surgery for adenocarcinoma of the gastroesophageal junction (GEJ) type II: transthoracic esophagectomy vs. transhiatal extended gastrectomy (CARDIA trial). Analyzing in a multicenter international setting the optimal surgical strategy for tumors at the oesophago-gastric junction. This trial is now recruiting in collaboration with The University of Koln. Deutsches Register Klinischer Studien. DRKS-number: 00016923. Federal Ministry for Education and Research. Bundesministerium für Bildung und Forschung (BMBF) (grant number 01KG1816). Eu 1.940.000

2018-present. G.J.Meijer. Preoperative Image-guided Identification of Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer (PRIDE). NCT03474341. KWF (10291) Eu 890.260

2020-present Principal investigator. Paravertabral catheter versus epidural anagesia in minimally invasive esophageal resection : a RCT (PEPMEN trail). ZonMw (852002004) Eu 392.650

Research Output (549)

The Comprehensive Complication Index versus Clavien-Dindo grading after laparoscopic and open D2-gastrectomy in the multicenter randomized LOGICA-trial

Triemstra Lianne, de Jongh Cas, Tedone Fabrizio, Brosens Lodewijk A.A., Luyer Misha D.P., Stoot Jan H.M.B., Lagarde Sjoerd M., van Hillegersberg Richard, Ruurda Jelle P., Brenkman Hylke J.F., van der Veen Arjen, Nieuwenhuijzen Grard A.P., Ponten Jeroen E.H., Tegels Juul J.W., Hulsewe Karel W.E., Wijnhoven Bas P.L., Lanschot Jan J.B., de Steur Wobbe O., Hartgrink Henk H., Kouwenhoven Ewout A., van Det Marc J., Wassenaar Eelco B., van Duijvendijk P., Draaisma Werner A., Broeders Ivo A.M.J., van der Peet Donald L., Gisbertz Suzanne S., Dec 2023, In: European Journal of Surgical Oncology. 49 , p. 1-8

Neoadjuvant Chemoradiotherapy Versus Chemotherapy for the Treatment of Locally Advanced Esophageal Adenocarcinoma in the European Multicenter ENSURE Study

Elliott Jessie A, Klevebro Fredrik, Mantziari Styliani, Markar Sheraz R, Goense Lucas, Johar Asif, Lagergren Pernilla, Zaninotto Giovanni, van Hillegersberg Richard, van Berge Henegouwen Mark I, Schäfer Markus, Nilsson Magnus, Hanna George B, Reynolds John V, 1 Nov 2023, In: Annals of surgery. 278 , p. 692-700 9 p.

Impact of the Surgical Approach for Neoadjuvantly Treated Gastroesophageal Junction Type II Tumors:A Multinational, High-volume Center Retrospective Cohort Analysis

Wirsik Naita M, Schmidt Thomas, Nienhüser Henrik, Donlon Noel E, de Jongh Cas, Uzun Eren, Fuchs Hans F, Brunner Stefanie, Alakus Hakan, Hölscher Arnulf H, Grimminger Peter, Schneider Martin, Reynolds John V, van Hillegersberg Richard, Bruns Christiane J 1 Nov 2023, In: Annals of surgery. 278 , p. 683-691 9 p.

Laparoscopic ischemic conditioning of the stomach prior to esophagectomy induces gastric neo-angiogenesis

Schiffmann L. M., de Groot E., Albert M. C., Quaas A., Pinto dos Santos D., Babic B., Fuchs H. F., Walczak H., Chon S. H., Ruurda J. P., Kashkar H., Bruns C. J., Schröder W., van Hillegersberg R. Nov 2023, In: European Journal of Surgical Oncology. 49

Long-Term Survival Associated with Direct Oral Feeding Following Minimally Invasive Esophagectomy:Results from a Randomized Controlled Trial (NUTRIENT II)

Geraedts Tessa C M, Weijs Teus J, Berkelmans Gijs H K, Fransen Laura F C, Kouwenhoven Ewout A, van Det Marc J, Nilsson Magnus, Lagarde Sjoerd M, van Hillegersberg Richard, Markar Sheraz R, Nieuwenhuijzen Grard A P, Luyer Misha D P 5 Oct 2023, In: Cancers. 15

A robust semi-automatic delineation workflow using denoised diffusion weighted magnetic resonance imaging for response assessment of patients with esophageal cancer treated with neoadjuvant chemoradiotherapy

den Boer Robin, Siang Kelvin Ng Wei, Yuen Mandy, Borggreve Alicia, Defize Ingmar, van Lier Astrid, Ruurda Jelle, van Hillegersberg Richard, Mook Stella, Meijer Gert Oct 2023, In: Physics and Imaging in Radiation Oncology. 28

Hospital practice variation in the proportion of patients with esophagogastric cancer discussed during an expert multidisciplinary team meeting

Luijten Josianne C H B M, Vissers Pauline A J, Geerts Julie, Lemmens Valery E P, van Hillegersberg Richard, Beerepoot Laurens, Walraven Janneke E W, Curvers Wouter, Voncken Francine E M, van der Sangen Maurice, Verhoeven Rob H A, Nieuwenhuijzen Grard A P Sep 2023, In: European Journal of Surgical Oncology. 49

Impact of body composition and physical strength changes during chemoradiotherapy on complications and survival after oesophagectomy

den Boer R. B., Defize I. L., Veldhuis W., Steenhagen E., Kerst A., van Hillegersberg R., de Jong P. A., Ruurda J. P. 14 Aug 2023, In: European Journal of Surgical Oncology. 49

Surgical quality and prospective quality control of the D2-gastrectomy for gastric cancer in the multicenter randomized LOGICA-trial

de Jongh Cas, Triemstra Lianne, van der Veen Arjen, Brosens Lodewijk Aa, Nieuwenhuijzen Grard Ap, Stoot Jan Hmb, de Steur Wobbe O, Ruurda Jelle P, van Hillegersberg Richard, 12 Aug 2023, In: European Journal of Surgical Oncology. 49 8 p.

Effects of exercise after oesophagectomy on body composition and adequacy of energy and protein intake:PERFECT multicentre randomized controlled trial

Hiensch Anouk, Steenhagen Elles, van Vulpen Jonna K., Ruurda Jelle P., Nieuwenhuijzen Grard A.P., Kouwenhoven Ewout A., Groenendijk Richard P.R., van der Peet Donald L., Rosman Camiel, Wijnhoven Bas P.L., van Berge Henegouwen Mark I., van Laarhoven Hanneke W.M., van Hillegersberg Richard, Siersema Peter D., May Anne M. 1 Aug 2023, In: BJS open. 7

All research output

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