Infection and Immunity nieuws
Infection and Immunity nieuws
Dec 20: Mathematical modeler Ganna Rozhnova appointed as associate professor
Nine new associate professors were appointed at UMC Utrecht on 9 December 2022. The talented staff have been appointed based on performance as well as on their qualifications in research, teaching and management. Mathematical modeler dr. Ganna Rozhnova (Program Epidemiology of Infectious Diseases at the Julius Center) is one of the new associate professors. Her research aims to understand transmission dynamics and interventions for highly relevant emerging and established respiratory and sexually-transmitted viruses that require massive control efforts and have large societal impact (e.g., SARS-CoV-2, HIV, monkeypox, influenza, and CMV)." .
Read moreNew research on rare forms of arthritis
When people think of rheumatoid arthritis, most think of osteoarthritis. But there are also more rare forms of inflammatory arthritis.
Read moreNov 25: Virus-host interactions resolved through manipulation of viral and host gene expression
Human herpesvirus infections often go unnoticed, but they can be responsible for severe disease in susceptible individuals. As these viruses are difficult to clear from the body, Hendrik de Buhr from UMC Utrecht investigated host-virus interactions that are involved in herpesviruses circumventing the immune system for their own benefit. Identifying and characterizing these mechanisms advances the understanding of viral infections and might aid in the development of new antiviral approaches.
Read moreAntibodies promising against Staphylococcus aureus infections
The opportunistic bacterium Staphylococcus aureus can easily develop resistance against antibiotics due to the formation of biofilm, where bacteria are surrounded by a self-made extracellular layer that prevents the antibiotic from reaching the bacterium. PhD research by Lisanne de Vor has shown that antibodies (coupled to specific enzymes) have the potential to degrade biofilm. If confirmed in clinical studies, this could result in development of antibody therapy that would make a resistant bacterium sensitive again for antibiotics.
Read moreNov 22: Prednisolone does not improve sense of smell after COVID-19
In a study executed by UMC Utrecht it was demonstrated that after prednisolone does not improve sense of smell after COVID-19. In addition, in most patients – irrespective of prednisolone use - sense of smell gradually improved over time. The authors recommend not to prescribe prednisolone for patients with persistent smell and/or taste disorders after COVID-19.
Read moreNov 21: The best antibiotic treatment for each sepsis patient
At UMC Utrecht, much scientific research is being conducted with the objective to prevent or reduce antibiotic resistance. In one of these studies, researchers are investigating which antibiotic treatment provides the best outcome in adults hospitalized with sepsis. This will allow this patient group in the future to receive the optimal antibiotic treatment based on sound scientific evidence. These results also contribute to a careful antibiotic policy that inhibits the development of antibiotic resistance.
Read moreNov 19: The gut microbiome is a reservoir for antimicrobial resistance genes
The gut microbiome forms a reservoir for opportunistic pathogens as well as for antimicrobial resistance genes. This finding is important because it offers a deeper insight in the dynamics and mechanism of antimicrobial resistance development. This project – supported by a grant from the Netherlands Centre for One Health - was performed by Paul Stege who defended his PhD thesis on November 9, 2022 at Utrecht University.
Read moreA solution is near for babies with RSV
One in 56 healthy, full-term babies in Europe is hospitalised due to an infection with the Respiratory Syncytial Virus (RSV), according to a new study led by Prof Dr Louis Bont of UMC Utrecht.
Read moreNov 10: Improving HIV treatment monitoring in resource-limited settings
Therapy failure is a threat to the health of people living with HIV, especially in resource-limited settings. Initiatives to reduce treatment failure such as stricter cut-off points for viral suppression, better clinical follow-up and improved HIV therapy monitoring can greatly reduce therapy failure. These are the main take-aways by Lucas Hermans from UMC Utrecht in his PhD thesis that he will defend on November 15, 2022.
Read moreNov 2: Alterations of dendritic cells and monocytes contribute to disease process in Sjögren Syndrome
A population of rare immune cells (type 2 conventional dendritic cells) are altered in Sjögren patients as well as in non-Sjögren sicca patients, and they have an important contribution to the disease. In addition, it was found that monocytes are affected and reshaped by the disease environment. These are the main findings of the PhD research by Ana Pinheiro Lopes at UMC Utrecht who defended her thesis on November 1, 2022.
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