prof. dr. P.A.F.M. (Pieter) Doevendans
prof. dr. P.A.F.M. (Pieter) Doevendans
- Division of Heart & Lungs
Research Programs
Biography
Biography
Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books
Side Activities
- Member of the Scientific Board, Netherlands Heart Institute
- Chairman Steering committee Heart and Vascular Center
- Advisor AMT Utrecht
- Advisor and shareholder HeartEye
Fellowship and Awards
Honors
- Fellow of the European Society of Cardiology, 2000
- Honorary Professor Yantai Yuhuangding Hospital, China, 2007
- Visiting Professor Harvard University, USA, 2007-2009
- Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
- Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014
Research grants obtained
- NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
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The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".
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NIH: "The role of the min K gene". Grant with R.S. Kass.
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The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.
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The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)
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The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.
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Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)
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The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)
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ICIN: Molecular genetic basis of cardiovascular disease (2000)
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ICIN: Human genetics and cardiovascular developement (2000)
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NHS: Dekker program: Vanessa van Empel (2001-2004)
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STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)
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BSIK: Weefsel op maat (2003)
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Bekales Research Grant – Cardiology 2004, candidature.
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Bekales Research Grant (2005)
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NHS: Translational medicine: stem cell applications (2006)
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ICIN: Stem cells from patients with genetic cardiac disease (2007)
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BMM: SMARTCARE: cardiac repair with microtissues (2008)
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NIRM: Stem cells as disease models (2009)
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ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
Phase A1 preclinical PL €300.000 (total project €2.0M) -
CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
(Total project 0,5M) -
CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)
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Leducq (Total project 6 M€) (2018)
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RegMed: Cardiovascular Moonshot (4 M€) (2018)
Research Output (994)
Balducci Valentina, Scardigli Francesco, Harakalova Magdalena, Peter. van Tintelen J., Doevendans Pieter A., Costa Kevin D., Turnbull Irene C., P. G. Sluijter Joost, Stillitano Francesca Oct 2023, In: Stem Cell Research. 72
Rudiktyo Estu, Soesanto Amiliana M, Cramer Maarten J, Yonas Emir, Teske Arco J, Siswanto Bambang B, Doevendans Pieter A Oct 2023, In: Journal of cardiovascular imaging. 31 , p. 191-199 9 p.
Kaffka Genaamd Dengler Selma E, Mishra Mudit, van Tuijl Sjoerd, de Jager Saskia C A, Sluijter Joost P G, Doevendans Pieter A, van der Kaaij Niels P 8 May 2023, In: ASAIO journal. 69 , p. 774-781 8 p.
Crnko Sandra, Printezi Markella I., Zwetsloot Peter Paul M., Leiteris Laurynas, Lumley Andrew I., Zhang Lu, Ernens Isabelle, Jansen Tijn P.J., Homsma Lilian, Feyen Dries, van Faassen Martijn, du Pré Bastiaan C., Gaillard Carlo A.J.M., Kemperman Hans, Oerlemans Marish I.F.J., Doevendans Pieter A.F.M., May Anne M., Zuithoff Nicolaas P.A., Sluijter Joost P.G., Devaux Yvan, van Laake Linda W. May 2023, In: EBioMedicine. 91
Maas Renee G C, Beekink Tess, Chirico Nino, Snijders Blok Christian J B, Dokter Inge, Sampaio-Pinto Vasco, van Mil Alain, Doevendans Pieter A, Buikema Jan W, Sluijter Joost P G, Stillitano Francesca 10 Mar 2023, In: Journal of visualized experiments : JoVE.
Meijs Timion A., Van Tuijl Rick J., Van Den Brink Hilde, Weaver Nick A., Siero Jeroen C.W., Van Der Worp H. Bart, Braun Kees P.J., Leiner Tim, De Jong Pim A., Zwanenburg Jaco J.M., Doevendans Pieter A., Voskuil Michiel, Grotenhuis Heynric B. 11 Jan 2023, In: European heart journal open. 3 10 p.
van den Hoogen Patricia, Huibers Manon M.H., van den Dolder Floor W., de Weger Roel, Siera-de Koning Erica, Oerlemans Marish I.F., de Jonge Nicolaas, van Laake Linda W., Doevendans Pieter A., Sluijter Joost P.G., Vink Aryan, de Jager Saskia C.A. Jan 2023, In: Biology. 12
Henkens M.T.H.M., van Ast J. F., te Riele A.S.J.M., Houweling A. C., Amin A. S., Nijveldt R., Antoni M. L., Li X., Wehrens S. M.T., von der Thüsen J. H., Damman K., ter Horst E. N., Manintveld O. C., Abma-Schouten R. Y., Niessen H. W.M., Silljé H. H.W., Jukema J. W., Doevendans P. A. Jan 2023, In: Netherlands Heart Journal. 31 , p. 16-20 5 p.
Zepeda-Echavarria Alejandra, de van Leur Rutger R.van, van Sleuwen Meike, Hassink Rutger J., Wildbergh Thierry X., Doevendans Pieter A., Jaspers Joris, van Es René 2023, In: JMIR Cardio. 7
Taha Karim, van de Leur Rutger R., Vessies Melle, Mast Thomas P., Cramer Maarten J., Cauwenberghs Nicholas, Verstraelen Tom E., de Brouwer Remco, Doevendans Pieter A., Wilde Arthur, Asselbergs Folkert W., van den Berg Maarten P., D’hooge Jan, Kuznetsova Tatiana, Teske Arco J., van Es René 2023, In: International Journal of Cardiovascular Imaging. 39 , p. 2149-2161 13 p.