Group Otten
Group Otten
About uitklapper, klik om te openen
Our primary research interest is focused on humoral immunity including associated effector mechanisms. This is studied in lung and kidney transplantation aimed at preventing rejection, as well as in systemic lupus erythematosus (SLE), food allergy and urticaria in order to improve diagnosis and treatment. Our research group leads the national PROCARE consortium with the purpose to modernize kidney allocation by studying the impact of pretransplant humoral allo- and auto-immunity and associated effector mechanisms in approximately 5000 kidney transplants. Together with dr. Maarten Limper, clinical immunologist, early diagnosis of SLE and relevant symptoms are investigated by defining novel patterns of multiple autoantibodies. Together with the group of dr. André Knulst, Dermatologist, studies are conducted in order to predict (the severity of) food allergy and urticaria aimed to find new leads for therapeutic intervention and new biomarkers to improve diagnostics.
Research program uitklapper, klik om te openen
Infection and Immunity
Research interest uitklapper, klik om te openen
- Humoral immunity
- Kidney- and lung transplantation
- Systemic Lupus Erythematosus
- Food allergy
Group members uitklapper, klik om te openen
Group leaders
- H.G. Otten Associate Professor
- prof. dr. A.C. Knulst Full Professor
- M. Limper Assistant Professor - medical
Post-docs
- dr. S. Haitjema
- dr. D. Senejohhny
- dr. L. Reteig
Research technicians
- Stans den Hartog Jager
- Tineke Kardol-Hoefnagel
PhD students
- PhD Students
- Anna Ehlers
- Tammo Brunekreef
- Mehran Alizadeh Aghdam
Key publications uitklapper, klik om te openen
- Kamburova, E. G., et al. (2019). "Antibodies against ARHGDIB are associated with long-term kidney graft loss." Am J Transplant. View
- Kamburova, E. G., et al. (2018). "Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant." Am J Transplant 18(9): 2274-2284. View
- Ehlers, A. M., et al. (2019). "Ara h 7 isoforms share many linear epitopes: Are 3D epitopes crucial to elucidate divergent abilities?" Clin Exp Allergy. View
- Budding, K., et al. (2018). "The Autoimmune-Associated Single Nucleotide Polymorphism Within PTPN22 Correlates With Clinical Outcome After Lung Transplantation." Front Immunol 9: 3105. View
- Kamburova, E. G., et al. (2018). "Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure." J Am Soc Nephrol 29(9): 2279-2285. View