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Group Otten

  1. About
  2. Research program
  3. Research interest
  4. Contact
  5. Group members
  6. Key publications
  7. Consortium procare

About

Our primary research interest is focused on humoral immunity including associated effector mechanisms. This is studied in lung and kidney transplantation aimed at preventing rejection, as well as in systemic lupus erythematosus (SLE), food allergy and urticaria in order to improve diagnosis and treatment. Our research group leads the national PROCARE consortium with the purpose to modernize kidney allocation by studying the impact of pretransplant humoral allo- and auto-immunity and associated effector mechanisms in approximately 5000 kidney transplants. Together with dr. Maarten Limper, clinical immunologist, early diagnosis of SLE and relevant symptoms are investigated by defining novel patterns of multiple autoantibodies.  Together with the group of dr. André Knulst, Dermatologist, studies are conducted in order to predict (the severity of) food allergy and urticaria aimed to find new leads for therapeutic intervention and new biomarkers to improve diagnostics.

Research program

Infection and Immunity

Research interest

  • Humoral immunity
  • Kidney- and lung transplantation
  • Systemic Lupus Erythematosus
  • Food allergy

Contact

Henny Otten

Group members

Group leaders 

Post-docs

  • dr. S. Haitjema
  • dr. D. Senejohhny
  • dr. L. Reteig 

Research technicians

  • Stans den Hartog Jager
  • Tineke Kardol-Hoefnagel

PhD students

  • PhD Students
  • Anna Ehlers
  • Tammo Brunekreef
  • Mehran Alizadeh Aghdam

Key publications

  1. Kamburova, E. G., et al. (2019). "Antibodies against ARHGDIB are associated with long-term kidney graft loss." Am J Transplant. View
  2. Kamburova, E. G., et al. (2018). "Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant." Am J Transplant 18(9): 2274-2284. View
  3. Ehlers, A. M., et al. (2019). "Ara h 7 isoforms share many linear epitopes: Are 3D epitopes crucial to elucidate divergent abilities?" Clin Exp Allergy. View
  4. Budding, K., et al. (2018). "The Autoimmune-Associated Single Nucleotide Polymorphism Within PTPN22 Correlates With Clinical Outcome After Lung Transplantation." Front Immunol 9: 3105. View 
  5. Kamburova, E. G., et al. (2018). "Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure." J Am Soc Nephrol 29(9): 2279-2285. View

Consortium procare

Nierstichting Consortium 2013 PROCARE

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